Hawaii is 6-5 and in second place in the Mountain Pacific Sports Federation's Pacific Division and 8-6 overall.
The 'Bows are ranked No. 8 in the Volleyball Monthly Poll and No. 7 in the USA Today/AVCA Coaches Top 15 Poll.
The Matadors are 3-6 in the MPSF's Mountain Division and 6-7 overall.
Lee stepped into the lineup midway through the first game of an 0-3 loss to UCLA last Friday, as Hawaii head coach Mike Wilton expressed disappointment in Vaughan's play.
Vaughan is the country's second-leading assist man, averaging 17.84 per game.
Lee engineered Hawaii's offense against UC Irvine in a 15-4, 15-12, 15-5 victory on Saturday, dishing out 52 assists in his first career start at setter.
Four 'Bows checked into double figures in that win, which snapped a four-game road losing streak.
Jason Ring led with 16 kills and a .400 hitting percentage.
Coming into tonight's match with the Matadors, middle blocker Sivan Leoni is first in the MPSF and third in the nation in hitting percentage at .464.
Middle blocker Rick Tune's 1.68 blocks per game average makes him seventh in the nation that department.
Cal State Northridge is led by former 'Bow Dan Fisher, who starts at setter.
Fisher left Hawaii for the Matadors last season and is ranked fifth in the nation in service ace average.
Hawaii leads the series with Cal State Northridge, 24-7. In Honolulu, the 'Bows are 11-3 against the Matadors.
In their last home series, the 'Bows swept San Diego State (Feb. 21-22).
The Matadors would like to end a three-match losing streak that began when Loyola-Marymount (sixth in the Mountain Division, 3-7) upset them in four games on Feb. 20.
All six of Cal State Northridge's other losses have come at the hands of higher ranked teams.
Since the opening of the arena in 1994, the Rainbows have posted a 36-5 record there. They are 34-4 in regular-season matches and 2-1 in postseason matches.
Hawaii's longest regular-season streak at the arena is 17 games, beginning Feb. 20, 1995 against UC San Diego and ending March 1, 1996, against UCLA.
Today: Hawaii vs. Cal State Northridge, 7 p.m. and Saturday at 7:30 p.m.